Drug Which Fights H1N1- Oseltamivir

H1N1 is spreading globally nowadays. Many death case reported due to H1N1. Comunity is start to scare and panic of this pandemic events. Though no cure is discovered until now , we still left 1 type of medication who can withstand H1N1 temporarily. This is one of our antiviral drugs , Oseltamivir.

This drug might be strange to population but it is famous in the health care professional group. They prefer called it Tamiflu (orginal brand name). It is used as prophylaxis and treatment in virus influenza infection such as H1N1. Anyhow , oseltamivir is not drug who can 100% treat H1N1.

Here is some drug information about Oseltamivir :

Oseltamivir is a prodrug. It need body enzyme to activate to become the active form, oseltamivir carboxylate. This drug will inhibited the influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.

Oseltamivir is extensively converted to oseltamivir carboxylate by esterases located predominantly in liver. Absorbed oseltamivir and oseltamiver carboxylate are mainly eliminated in urine (70%). Meanwhile the other (20%) will eliminate in in feces.

Indication of oseltamivir is for treatment and prevention of the Influenza. For the treatment dose of influenza :

Patient or children who is > 40kg will be given 75mg oseltamivir twice daily for 5 days when they clinically present typical symptoms of influenza. It only used when influenza virus is circulating in the comunity.

Meanwhile for the prevention dose of influenza :

Patient or children who is > 40kg will be given of 75mg osteltamivir once daily for 10 days . Therapy should be initiate as soon as possible after close contact with individual with infected patients

For the patient who is children or weight under 40kg , dosage adjustment need to be done based on their body weight.

Side Effects

Common Side Effects include :

Vomiting , Nausea , Diarrhoea , Abdominal Pain , Acute Bronchitis , Dizziness and Fatigue are the common side effects of oseltamivir.

For more information , please visit : http://www.healthmutuals.net/health-care/drug-which-fights-h1n1-oseltamivir/

p/s : this article is picked from www.healthmutuals.net

Medication Which Interact with Vitamin E

Warfarin

Vegetable which dark in color and nuts are rich in vitamin E. When take with warfarin , vitamin E in the vegetable might have synergistic effects and lead to uncontrolled bleeding. It can be lethal. Please consult pharmacist if you are taking the anticoagulant agent for more detail.

Medication Which Interact with Vitamin D

Digoxin

Fishes contain high calcium content. When we take extra of this diet. Hypercalcemia might occur (high concentration in blood). It might lead to tired , nausea and vomiting , thinking disturbance etc. When take concurrently with digoxin , it might lead to irregular of the heart and heart arrithymia might occur which can lead to vital.

Medication Which Interact with Vitamin C

Vitamin C is water soluble vitamin which prevent us from scurvy and bleeding in the vascular. In addition, it also maintain the normal function of our blood circulation system. Daily usage of this medication is 60-70mg. Anyhow; vitamin C also might interact with some of the medication:

Warfarin

Vitamin C can interact with warfarin and lower down the effect of warfarin. It is advisable warfarin take 1 hour before dinner. In addition , patient need to restrict the food consumption which rich in Vitamin C.

Food Which Interact with AntiParkinson Medication

Levadopa and Madopar are common medication for anti Parkinson. When taking with food rich with vitamin B6 (fishes, beefs, gingko & alomond etc) , it will increase the metabolism rate for anti Parkinson medication and lead to ineffective in our body.

Food Which Interact with H2 Antagonist

H2 antagonist which mainly treat for over gastric secretion in the body. It mainly inhibit the secretion of the acid in the stomach. Anyhow , H2 antagonist can interact with many foods such as

Fishes

Fishes contain rich of Vitamin B12 which essential for maintain our body health. Anyhow , H2 antagonist can inhibit the absorption of Vitamin B12 . Patient who taking the H2 antagonist is advice to take more food which rich in Vitamin B12 for maintain normal body health.

Caffeine

Caffeine can stimulate the secretion of acid in the stomach. In addition , caffeine can inhibit the effect of the H2 antagonist. Conclusion, the acid secretion can lead more harm.

Cigarettes

Cigarettes can stimulate the acid secretion and destroy the stomach protective layer. When take together with H2 antagonist , it will decrease the effect of the medication.
It is advisable to take cigarettes 2 hours after taking the H2 antagonist.

Example : Cimetidine , Famotidine , Ranatidine

Food Might Increase the Effect of Antihistamine

Antihistamine is widely used in the flu medication for clear the running rose and eliminate any allergy reaction which can lead to flu. In addition, it also effective in treating any allergy series which happen include eczema , itchiness and rashes in the body.

Due some type of antihistamine might lead to dizziness. It is not advisable to take with alcohol. This combination might increase the severity of the drowsiness and dizziness. It is due alcohol slow down the mechanism of CYP 450 which is essential in metabolism of antihistamine. The drug effect will delay and lead to severe drowsiness.

Food Might Lower Down Effect Of Flu Medication.

Carbonated drink when take with the flu medication, the effect of might decrease. It is due to carbonated inhibit the absorption of the flu medication into our blood circulation system. It is advisable to take flu medication with plain water (milk also not recommend). Aspirin which contain in the flu medication can’t absorb in to body due to the carbonated drink. IN addition, this also can harm our liver function.

Cake and cheesy biscuit also can lower down the effect of flu medication. Aspirin / paracetamol in the medication will get bind with sugar in the food, chelation will occur. The medication can’t be absorbed and the effect will be slow down. It is advisable take only plain food when sick to avoid any interaction whole might slow down the recovery of the medication.

Food Might Increase Effect of Flu Medication

Flu medication contain multi combination drug. When flu medication take concurrently with garlic and Chili , it will increase the risk of gastrointestinal bleeding. It is due to garlic and chili contain stimulating effect in the stomach. It might destroy or slow down the formation of the protective layer in the stomach. In addition, Flu medication contains NSAID’s might worsen this condition. If the NSAID’s content too concentrated, the chances of gastrointestinal bleeding and gastro pain might occurred.

Alcohol is can alter our liver function (CYP450) in our body. It slows down the mechanism of CYP450. When take with flu medication , over dosage might occurred due to slow metabolism of the drug. Dos adjustment is needed.

About Cigarette 2

About Cigarette 2

Cigarette also can increase some of the effect of the medication since the chemical substance which react to the medication.

• Warfarin

Cigarette can increase the efficacy of the warfarin. Symptom of overdosage can happen if warfarin take together with cigarette. Internal bleeding, uncontrolled bleeding and gastrointestinal bleeding might occurred.

Brand name Of This Medication : Marevan , Coumadin

• OCP (Oral Contraceptive Pill)

Research showed that cigarette user who smoked for > 15 cigarettes per day when taking OCP together , is 50% more chances to develop stroke and angina (side effect of OCP)

• Insulin Therapy

Cigarette user advised not to smoke pre and post 2 hour when injecting insulin since cigarette can decrease 10% of absorption of insulin and efficacy relatively drop to 10%.

About Cigarette

About Cigarette

Although cigarette cannot consider as food, taking this can lead a big impact to some of the pharmacokinetic in our system. Now, we will discuss about the relationship between medication & cigarette.

Cigarette can decrease the efficacy of some medication. Cigarette can increase the clearance of some of the medication from our body. This will lead to ineffective of this medication when taking the cigarette. Smoker advised to take medication pre and post 2 hour taking the cigarette.

Common medication which interact with cigarette:

· Theophylline

· Antipyrine

· Lidocaine

· Propanolol

· Imipramine

· Chlorpromazine

· Acetaminophen